Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance

Drug Metab Pharmacokinet. 2012;27(1):55-67. doi: 10.2133/dmpk.dmpk-11-rv-121. Epub 2011 Dec 20.


CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions.

Publication types

  • Review

MeSH terms

  • Biotransformation
  • Cytochrome P-450 CYP2D6 / genetics*
  • Cytochrome P-450 CYP2D6 / metabolism*
  • Drug Interactions
  • Genetic Predisposition to Disease
  • Humans
  • Pharmacogenetics / methods
  • Pharmacokinetics*
  • Polymorphism, Genetic*


  • Cytochrome P-450 CYP2D6