Anterior mediastinal mass secondary to histoplasmosis

Ann Thorac Surg. 2012 Jan;93(1):e9-10. doi: 10.1016/j.athoracsur.2011.07.093.


Histoplasmosis in the mediastinum is an uncommon diagnosis that presents similarly to other benign and neoplastic conditions encountered in the chest. Here we describe a 36-year-old woman who presented with dyspnea secondary to a large anterior mediastinal mass that was biopsy and culture negative for neoplasm or infection. Video-assisted thoracoscopic surgery biopsy confirmed a large anterior mediastinal mass adherent to the aorta, which contained foci of histoplasmosis species. She is currently undergoing a long postoperative course of itraconozole and an empiric course of oral steroids to prevent development of fibrosing mediastinitis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy / methods
  • Bronchoscopy / methods*
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Histoplasmosis / diagnosis*
  • Histoplasmosis / surgery
  • Humans
  • Mediastinal Diseases / diagnosis*
  • Mediastinal Diseases / surgery
  • Thoracic Surgery, Video-Assisted*
  • Tomography, X-Ray Computed