Satellite cells, the engines of muscle repair

Nat Rev Mol Cell Biol. 2011 Dec 21;13(2):127-33. doi: 10.1038/nrm3265.

Abstract

Satellite cells are a heterogeneous population of stem and progenitor cells that are required for the growth, maintenance and regeneration of skeletal muscle. The transcription factors paired-box 3 (PAX3) and PAX7 have essential and overlapping roles in myogenesis. PAX3 acts to specify embryonic muscle precursors, whereas PAX7 enforces the satellite cell myogenic programme while maintaining the undifferentiated state. Recent experiments have suggested that PAX7 is dispensable in adult satellite cells. However, these findings are controversial, and the issue remains unresolved.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Animals
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • Embryonic Development / genetics
  • Embryonic Development / physiology
  • Growth and Development / genetics
  • Growth and Development / physiology
  • Humans
  • Hypertrophy
  • Models, Biological
  • Muscle Development / genetics
  • Muscle Development / physiology
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / pathology
  • Muscle, Skeletal / physiology*
  • Paired Box Transcription Factors / genetics
  • Paired Box Transcription Factors / metabolism
  • Paired Box Transcription Factors / physiology
  • Regeneration / genetics
  • Regeneration / physiology*
  • Satellite Cells, Skeletal Muscle / cytology
  • Satellite Cells, Skeletal Muscle / metabolism
  • Satellite Cells, Skeletal Muscle / physiology*
  • Wound Healing / genetics
  • Wound Healing / physiology

Substances

  • Paired Box Transcription Factors