Hürthle cell medullary carcinomas of the thyroid gland

S Afr J Surg. 1990 Sep;28(3):95-7.


Two medullary carcinomas of the thyroid (MCTs) composed entirely of Hürthle (oncocytic or oxyphilic) cells and containing follicular structures are described. Immunocytochemical analysis showed these tumours to be calcitonin-, carcino-embryonic antigen- and neuron-specific enolase-positive. The essence of this communication is twofold. Firstly, it highlights and draws attention to this unusual variant of MCT, which may be encountered at frozen section and misdiagnosed as a Hürthle cell tumour of follicular cell origin. Secondly, it undertakes a concise overview of the immunocytochemistry of Hürthle cell thyroid neoplasms and MCT.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinoma / diagnosis
  • Carcinoma / pathology*
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Thyroid Neoplasms / diagnosis
  • Thyroid Neoplasms / pathology*