Background: Red scrotum syndrome is a rare and chronic disease affecting males in their second half of life. It is characterized by erythema with sharpborders, no scaling but burning and pain sensations.
Main observations: We report about two cases treated successfully with either doxycycline and tacrolimus or gabapentine.
Conclusion: For practical purposes we suggest to start treating red scrotum syndrome with doxycycline for 2 weeks and use gabapentin as second-line treatment when doxycycline fails.
Keywords: differential diagnosis; doxycycline; gabapentine; neurogenic inflammation; red scrotum syndrome.