A comprehensive review of current treatments for granulomatous cheilitis

Br J Dermatol. 2012 May;166(5):934-7. doi: 10.1111/j.1365-2133.2011.10794.x.


Granulomatous cheilitis (GC) is a poorly understood disease process belonging to the larger group of orofacial granulomatosis. The treatment of GC has proven exceedingly difficult. While various treatments have been applied to GC, there has been no uniform or predictably successful model demonstrated in the literature. Poor understanding of the aetiological mechanisms underpinning GC has significantly hampered the development of an effective approach to treatment. Those therapies that have shown promise principally consist of agents with anti-inflammatory activity such as corticosteroids and immunomodulatory medications. On a careful review of the literature, we have found no systematic review and assessment of current treatments. We seek to address this absence in the available literature by providing a consolidated overview of current treatment for GC.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Anti-Bacterial Agents / therapeutic use*
  • Anti-Inflammatory Agents / therapeutic use*
  • Clofazimine / therapeutic use*
  • Humans
  • Immunologic Factors / therapeutic use*
  • Melkersson-Rosenthal Syndrome / drug therapy*
  • Melkersson-Rosenthal Syndrome / surgery


  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Immunologic Factors
  • Clofazimine