HLA-B*51 and Behçet Disease

Ocul Immunol Inflamm. 2012 Feb;20(1):37-43. doi: 10.3109/09273948.2011.634978. Epub 2011 Dec 21.


Behçet disease (BD) is a multisystem inflammatory disorder of unknown etiology. BD has a multifactorial pathogenesis, and genetics plays a critical role in the development of the disease. Association of HLA-B5/B*51 has been recognized as the strongest genetic susceptibility factor for BD discovered so far. Pathogenic role of HLA-B*51 in BD has yet to be clarified, and available data suggest that there is possibly no single mechanism associated with HLA-B*51. HLA-B*51 may accomplish its effects as a combination of different HLA class I-associated functions and/or structural properties of HLA-B*51 heavy chain. There is no evidence supporting the use of HLA-B*51 as a diagnostic or prognostic marker for BD, and more clinical data must be collected in addition to basic immunological studies to exploit the potential of HLA-B*51 as a biomarker for BD management.

Publication types

  • Review

MeSH terms

  • Animals
  • Behcet Syndrome* / genetics
  • Behcet Syndrome* / immunology
  • Behcet Syndrome* / metabolism
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • HLA-B Antigens* / genetics
  • HLA-B Antigens* / immunology
  • HLA-B Antigens* / metabolism
  • Humans
  • Immunity, Cellular*
  • Polymorphism, Genetic*


  • HLA-B Antigens
  • HLA-B5 antigen