Circulating miR-423_5p fails as a biomarker for systemic ventricular function in adults after atrial repair for transposition of the great arteries

Int J Cardiol. 2013 Jul 15;167(1):63-6. doi: 10.1016/j.ijcard.2011.11.082. Epub 2011 Dec 20.

Abstract

Background: Recently, the microRNA miR-423_5p was identified as a biomarker for left ventricular heart failure. Its role in patients with a systemic right ventricle and reduced ejection fraction after atrial repair for transposition of the great arteries has not been evaluated.

Methods: In 41 patients and 10 age- and sex-matched healthy controls circulating miR-423_5p concentration was measured and correlated to clinical parameters, cardiac functional parameters assessed by magnetic resonance imaging, and cardiopulmonary exercise testing.

Results: Levels of circulating miR-423_5p showed no difference between patients and controls. Further, there was no correlation between miR-423_5p and parameters of cardiopulmonary exercise testing or imaging findings.

Conclusions: In patients with a systemic right ventricle and reduced ejection fraction miR-423_5p levels are not elevated. Therefore, circulating miR-423_5p is not a useful biomarker for heart failure in this patient group.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Female
  • Heart Atria / pathology
  • Heart Atria / surgery
  • Heart Failure / blood*
  • Heart Failure / diagnosis
  • Humans
  • Male
  • MicroRNAs / blood*
  • MicroRNAs / physiology
  • Transposition of Great Vessels / blood*
  • Transposition of Great Vessels / diagnosis
  • Transposition of Great Vessels / surgery*
  • Ventricular Function, Right / physiology*

Substances

  • Biomarkers
  • MIRN423 microRNA, human
  • MicroRNAs