A measure of explained risk in the proportional hazards model

Biostatistics. 2012 Apr;13(2):315-25. doi: 10.1093/biostatistics/kxr047. Epub 2011 Dec 21.


A measure of explained risk is developed for application with the proportional hazards model. The statistic, which is called the estimated explained relative risk, has a simple analytical form and is unaffected by censoring that is independent of survival time conditional on the covariates. An asymptotic confidence interval for the limiting value of the estimated explained relative risk is derived, and the role of individual factors in the computation of its estimate is established. Simulations are performed to compare the results of the estimated explained relative risk to other known explained risk measures with censored data. Prostate cancer data are used to demonstrate an analysis incorporating the proposed approach.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomarkers, Tumor / blood
  • Biostatistics
  • Confidence Intervals
  • Humans
  • Male
  • Models, Statistical
  • Neoplastic Cells, Circulating / pathology
  • Prognosis
  • Proportional Hazards Models*
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / mortality
  • Risk*
  • Survival Analysis


  • Biomarkers, Tumor