Date fruit extract is a neuroprotective agent in diabetic peripheral neuropathy in streptozotocin-induced diabetic rats: a multimodal analysis

Oxid Med Cell Longev. 2011;2011:976948. doi: 10.1155/2011/976948. Epub 2011 Dec 1.

Abstract

Background: To study the effects of an aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae) diet on diabetic polyneuropathy (DPN) in streptozotocin- (STZ-) induced diabetic rats.

Methods: The effects of a date fruit extract (DFE) diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with a nondiabetic control group, diabetic control group (sham), and vehicle group with respect to the following parameters: open field behavioral test, motor nerve conduction velocity (MNCV), and morphological observations.

Results: In the model of STZ-induced of diabetic neuropathy, chronic treatment for 6 weeks with DFE counteracted the impairment of the explorative activity of the rats in an open field behavioral test and of the conduction velocity of the sciatic nerve (MNCV). In addition, pretreatment with DFE significantly reversed each nerve diameter reduction in diabetic rats.

Conclusion: DFE treatment shows efficacy for preventing diabetic deterioration and for improving pathological parameters of diabetic neuropathy in rats, as compared with control groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Chronology as Topic*
  • Diabetes Mellitus, Experimental / complications*
  • Diabetic Neuropathies / drug therapy*
  • Diabetic Neuropathies / physiopathology
  • Fruit*
  • Male
  • Motor Neurons / drug effects*
  • Motor Neurons / pathology
  • Motor Neurons / physiology
  • Neural Conduction / drug effects
  • Neuroprotective Agents / administration & dosage*
  • Neuroprotective Agents / adverse effects
  • Plant Extracts / administration & dosage*
  • Plant Extracts / adverse effects
  • Rats
  • Rats, Wistar
  • Sciatic Nerve / drug effects
  • Sciatic Nerve / pathology
  • Sciatic Nerve / physiopathology

Substances

  • Neuroprotective Agents
  • Plant Extracts