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, 105 (2), 340-4

Antagonism of Carbon Monoxide-Mediated Brain Lipid Peroxidation by Hyperbaric Oxygen

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Antagonism of Carbon Monoxide-Mediated Brain Lipid Peroxidation by Hyperbaric Oxygen

S R Thom. Toxicol Appl Pharmacol.

Abstract

The effects of oxygen at 1, 2, and 3, atmospheres absolute (ATA) were assessed on brain lipid peroxidation caused by carbon monoxide (CO) poisoning in a rat model. Oxygen at 3 ATA, but not 1 ATA, was found to prevent brain lipid peroxidation when administered to rats for 45 min, beginning 45 min subsequent to CO poisoning. Oxygen at 2 ATA had an intermediate effect. The action of hyperbaric oxygen could not be attributed to a more rapid diminution of carboxyhemoglobin, and appears to occur at the level of the brain tissue.

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