Antagonism of carbon monoxide-mediated brain lipid peroxidation by hyperbaric oxygen

Toxicol Appl Pharmacol. 1990 Sep 1;105(2):340-4. doi: 10.1016/0041-008x(90)90195-z.


The effects of oxygen at 1, 2, and 3, atmospheres absolute (ATA) were assessed on brain lipid peroxidation caused by carbon monoxide (CO) poisoning in a rat model. Oxygen at 3 ATA, but not 1 ATA, was found to prevent brain lipid peroxidation when administered to rats for 45 min, beginning 45 min subsequent to CO poisoning. Oxygen at 2 ATA had an intermediate effect. The action of hyperbaric oxygen could not be attributed to a more rapid diminution of carboxyhemoglobin, and appears to occur at the level of the brain tissue.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Carbon Monoxide / pharmacology*
  • Carboxyhemoglobin / metabolism
  • Hyperbaric Oxygenation
  • Kinetics
  • Lipid Peroxidation / drug effects*
  • Male
  • Malondialdehyde / metabolism
  • Oxygen / pharmacology*
  • Rats
  • Rats, Inbred Strains


  • Malondialdehyde
  • Carbon Monoxide
  • Carboxyhemoglobin
  • Oxygen