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Randomized Controlled Trial
. 2012 Oct;15(5):490-5.
doi: 10.3109/13697137.2011.631063. Epub 2011 Dec 23.

One-year Effects of Myo-Inositol Supplementation in Postmenopausal Women With Metabolic Syndrome

Affiliations
Randomized Controlled Trial

One-year Effects of Myo-Inositol Supplementation in Postmenopausal Women With Metabolic Syndrome

A Santamaria et al. Climacteric. .

Abstract

Objective: To evaluate the 12-month effect of myo-inositol treatment on some biochemical parameters of women affected by metabolic syndrome.

Methods: Eighty outpatient postmenopausal women, affected by metabolic syndrome, were enrolled in a 12-month study. All women were treated with a low-energy diet, and then they were randomly assigned to myo-inositol 2 g b.i.d. (n = 40) or placebo (n = 40). All the women were evaluated for serum glucose, insulin, HOMA-IR (Homeostasis Model Assessment-Insulin Resistance), triglycerides, total and high density lipoprotein cholesterol, body mass index (BMI), waist circumference and blood pressure at baseline and after 12 months of treatment.

Results: With the exception of BMI and waist circumference, after 12 months of treatment, all the parameters studied showed a significant improvement in the myo-inositol group compared to the control group. At the end of the study, in the myo-inositol group, the number of women without metabolic syndrome was eight (20%) whereas, in the control group, only one woman no longer had the metabolic syndrome after 12 months of diet.

Conclusions: Myo-inositol might be considered one of the insulin-sensitizing substances in the treatment of metabolic syndrome.

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