The functions of the nuclear envelope in mediating the molecular crosstalk between the nucleus and the cytoplasm

Curr Opin Cell Biol. 2012 Feb;24(1):71-8. doi: 10.1016/ Epub 2011 Dec 20.


Recent studies of the nuclear envelope (NE) have emphasized its role in linking the nuclear and cytoplasmic compartments of mammalian cells. The inner face of the NE is bound to chromatin and this interaction is involved in regulating DNA replication and transcription. The outer face of the NE binds to different components of the cytoskeleton, and these interactions are involved in nuclear positioning. Many disease causing mutations in genes encoding NE proteins cause significant changes in nuclear architecture and cytoskeletal interactions with the NE. These mutations are also providing important new insights into nuclear-cytoplasmic interactions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • Cytoplasm / metabolism*
  • Cytoskeleton / metabolism
  • Humans
  • Nuclear Envelope / metabolism*
  • Nuclear Proteins / metabolism
  • Organelle Shape


  • Nuclear Proteins