(In)organic anions as carbonic anhydrase inhibitors

J Inorg Biochem. 2012 Jun;111:117-29. doi: 10.1016/j.jinorgbio.2011.11.017. Epub 2011 Dec 1.

Abstract

Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread enzymes in all life kingdoms with five distinct genetic families known to date, the α-, β-, γ-, δ- and ζ-CAs. With the exception of the δ-class, which is less investigated to date, enzymes from the remaining classes found in vertebrates, corals, fungi, bacteria and archaea have been studied for their inhibition with simple inorganic anions as well as more complex inorganic and organic ones. In this paper we review the available data for the inhibition of these enzymes with all anions except sulfonamides and their bioisosteres (sulfamates, sulfamides) which have been reviewed earlier. Anion inhibitors are important both for understanding the inhibition/catalytic mechanisms of these enzymes and for designing novel types of inhibitors which may have clinical applications for the management of a variety of disorders in which CAs are involved. Environmental aspects of CO(2) fixation by CAs present in plants, corals, algae or diatoms and how this may be affected by inhibitors are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anions / chemistry*
  • Anions / pharmacology
  • Biocatalysis / drug effects
  • Carbonic Anhydrase Inhibitors / chemistry*
  • Carbonic Anhydrase Inhibitors / pharmacology
  • Carbonic Anhydrases / chemistry*
  • Carbonic Anhydrases / metabolism
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / metabolism
  • Models, Molecular
  • Protein Structure, Tertiary
  • Zinc / chemistry*
  • Zinc / metabolism

Substances

  • Anions
  • Carbonic Anhydrase Inhibitors
  • Isoenzymes
  • Carbonic Anhydrases
  • Zinc