Lessons from yeast for clathrin-mediated endocytosis

Nat Cell Biol. 2011 Dec 22;14(1):2-10. doi: 10.1038/ncb2403.


Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism*
  • Clathrin-Coated Vesicles / metabolism*
  • Humans
  • Membrane Proteins / metabolism*
  • Yeasts / metabolism*


  • Membrane Proteins