Shaping development with ESCRTs

Nat Cell Biol. 2011 Dec 22;14(1):38-45. doi: 10.1038/ncb2381.


Originally identified for their involvement in endosomal sorting and multivesicular endosome (MVE) biogenesis, components of the endosomal sorting complex required for transport (ESCRT) are now known to control additional cellular functions such as receptor signalling, cytokinesis, autophagy, polarity, migration, miRNA activity and mRNA transport. The diverse cell biological functions of ESCRT proteins are translated into a pleiotropic set of developmental trajectories that reflect the wide repertoire of these evolutionarily conserved proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endosomal Sorting Complexes Required for Transport / metabolism*
  • Humans
  • Multivesicular Bodies / metabolism*
  • Protein Transport


  • Endosomal Sorting Complexes Required for Transport