The effect of choroidal artery vasospasm on choroid plexus injury in subarachnoid hemorrhage: experimental study

Turk Neurosurg. 2011;21(4):477-82.

Abstract

Aim: We examined whether vasospasm of choroidal arteries (ChAs) may be resulted in ischemic injury in choroid plexus (CP) after subarachnoid hemorrhage (SAH).

Material and methods: This study has been conducted on 30 rabbits. Eight, fourteen and eight of them were used as control, SAH and SHAM groups, respectively. The volumes of choroidal arteries were examined and measured by using the micrometric microscope barr. Ischemic morphological changes of the choroid plexus cells and villus were examined as follows: cellular shrinkage (1 point), cytoplasmic condensation (2 points), angulation (3 points) and villus desquamation (4 points) were considered as 1st, 2nd, 3rd, 4th degree downward choroid plexus degeneration criteria. Degeneration scores of 1 to 4 criteria were calculated by summing the exacerbated ones with the existing one.

Results: Choroidal artery diameter&volume, and CP degeneration scores in three groups were evaluated: The mean volumes were 1.080 ± 0.650 mm³, 0.907 ± 0.330 mm³, 0.480 ± 0.175 mm³ and the degeneration scores of choroidal plexuses were scored as 0 and 1- 1, and 4- 3 and 10 in the control, SHAM and SAH groups respectively. A significant correlation between the degree of vasospasm and CP degeneration was found.

Conclusion: Vasospasm of choroidal arteries may be at a serious degree in cases with SAH incurs damages on choroid plexuses, and affects structures which play important roles in immune, endocrine, detoxifying, thermoregulatory, and secretory functions of the brain resulting in worsened prognosis.

MeSH terms

  • Animals
  • Cerebral Arteries / pathology
  • Cerebrospinal Fluid / metabolism
  • Choroid Plexus / blood supply*
  • Choroid Plexus / metabolism
  • Choroid Plexus / pathology*
  • Disease Models, Animal
  • Male
  • Rabbits
  • Subarachnoid Hemorrhage / complications*
  • Subarachnoid Hemorrhage / metabolism
  • Subarachnoid Hemorrhage / pathology*
  • Vasospasm, Intracranial / complications*
  • Vasospasm, Intracranial / metabolism
  • Vasospasm, Intracranial / pathology*