Treatment-related change versus tumor recurrence in high-grade gliomas: a diagnostic conundrum--use of dynamic susceptibility contrast-enhanced (DSC) perfusion MRI

AJR Am J Roentgenol. 2012 Jan;198(1):19-26. doi: 10.2214/AJR.11.7417.


Objective: The purpose of this article is to address radiation necrosis, pseudoprogression, and pseudoresponse relative to high-grade gliomas and evaluate the role of conventional MRI and, in particular, dynamic susceptibility contrast-enhanced perfusion MRI in assessing such treatment-related changes from tumor recurrence.

Conclusion: Posttreatment imaging assessment of high-grade gliomas remains challenging. Familiarity with the expected MR imaging appearances of treatment-related change and tumor recurrence will help distinguish these entities allowing appropriate management.

Publication types

  • Review

MeSH terms

  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / radiotherapy
  • Contrast Media
  • Diagnosis, Differential
  • Disease Progression
  • Glioma / diagnosis*
  • Glioma / pathology
  • Glioma / radiotherapy
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Necrosis / diagnosis
  • Necrosis / etiology
  • Neoplasm Recurrence, Local / diagnosis*
  • Radiation Injuries / diagnosis*


  • Contrast Media