Ulcerative Keratitis Following Particulate Elemental Gold Deposition

J Ocul Pharmacol Ther. 2012 Jun;28(3):323-5. doi: 10.1089/jop.2011.0144. Epub 2011 Dec 23.

Abstract

Purpose: To describe a case of 68-year-old male industrial chemist who received a chemical injury after a gold/amine compound exploded causing bilateral eye injuries. No apparent long-term problems were anticipated. After cataract extraction 40 years later, he developed a localized ulcerative keratitis adjacent to embedded gold in the cornea.

Methods: To describe the clinical features, management, and outcomes.

Results: Successful treatment with topical hydrocortisone was achieved. Subsequently, 3 further episodes of ulcerative keratitis were treated with topical steroid therapy without need for systemic immunosuppression. A systemic vasculitic/autoimmune screen was normal.

Discussion: Ocular chrysiasis is well recognized after systemic gold administration and is normally considered inert, but in this case exogenous gold deposition might have been a contributing factor to very localized and repeated episodes of stromal erosion in this man, many years after the original injury. To the best of our knowledge this is the first such reported case.

Publication types

  • Case Reports

MeSH terms

  • Accidents, Occupational*
  • Aged
  • Cataract / therapy
  • Chemical Industry*
  • Cornea / drug effects
  • Cornea / surgery
  • Corneal Ulcer / chemically induced*
  • Corneal Ulcer / drug therapy*
  • Gold / adverse effects*
  • Humans
  • Hydrocortisone / therapeutic use
  • Male

Substances

  • Gold
  • Hydrocortisone