Polymeric nanomaterials for islet targeting and immunotherapeutic delivery

Nano Lett. 2012 Jan 11;12(1):203-8. doi: 10.1021/nl203334c. Epub 2011 Dec 28.

Abstract

Here we report a proof-of-concept for development of pancreatic islet-targeting nanoparticles for immunomodulatory therapy of autoimmune type 1 diabetes. Modified with a unique islet-homing peptide, these polymeric nanomaterials exhibit 3-fold greater binding to islet endothelial cells and a 200-fold greater anti-inflammatory effect through targeted islet endothelial cell delivery of an immunosuppressant drug. Our findings also underscore the need to carefully tailor drug loading and nanoparticle dosage to achieve maximal vascular targeting and immunosuppression.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Immunosuppressive Agents / administration & dosage*
  • Immunosuppressive Agents / pharmacokinetics*
  • Immunotherapy / methods*
  • Islets of Langerhans / drug effects*
  • Islets of Langerhans / metabolism*
  • Mice
  • Nanocapsules / chemistry*
  • Polymers / chemistry*

Substances

  • Immunosuppressive Agents
  • Nanocapsules
  • Polymers