Incidence and mortality of Parkinson's disease in older Canadians

Parkinsonism Relat Disord. 2012 May;18(4):327-31. doi: 10.1016/j.parkreldis.2011.11.018. Epub 2011 Dec 24.

Abstract

Objective: To estimate the age-specific incidence of Parkinson's disease (PD) in elderly persons in the Canadian province of British Columbia (BC). All-cause and injury mortalities and relative risk of death for those persons with PD were also examined.

Methods: A historical cohort study was conducted using 5 provincial administrative databases from 1991/92 to 2000/2001. A series of algorithms based on the databases were created for case ascertainment of PD for persons 65 years or older. Crude and age-specific incidence and mortality rates were calculated using person-years of follow-up as the denominator. The impact of PD on all-cause and injury mortalities was examined using multivariate Cox regression models to provide adjusted hazard ratios.

Results: 10,910 incidence cases over 6,051,682 person-years of follow-up were identified. The crude annual incidence rate was 252 per 100,000 person-years. Over the nine year period, age standardized incidence for males ranged from 207 to 396 per 100,000 person-years and 127 to 259 per 100,000 person-years for females. Persons with PD were at a 43% greater risk of all-cause mortality and specifically, 51% greater risk of injury mortality.

Conclusions: Incidence of PD is substantially higher in advanced age with age adjusted increases for both all-cause and injury mortalities. These findings also highlight falls as a primary factor for injury mortality in PD.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging*
  • Algorithms
  • Canada / epidemiology
  • Cause of Death
  • Cohort Studies
  • Female
  • Humans
  • Incidence
  • Male
  • Parkinson Disease / epidemiology*
  • Parkinson Disease / mortality*
  • Retrospective Studies
  • Sex Factors
  • Statistics, Nonparametric