Long term follow-up of appendiceal and distal right-sided colonic inflammation

Endoscopy. 2012 Jan;44(1):95-8. doi: 10.1055/s-0031-1291443. Epub 2011 Dec 23.

Abstract

The aim of this study was to investigate the possibility of appendiceal orifice inflammation (AOI) as a preceding lesion in the development of ulcerative colitis. A total of 20 patients were identified (mean age 41.2 years; 11 males) who had ulcerative colitis-like inflammatory lesions at the appendiceal orifice without concomitant typical features of ulcerative colitis, such as rectal involvement. A total of 19 patients were followed up endoscopically for a mean duration of 18.4 months (range 2 - 84 months). Typical ulcerative colitis developed in five patients (25 %; four proctitis, one pancolitis) in a mean time of 18.4 months (range 2 - 36 months). Negative conversion of all inflammatory lesions occurred in seven patients (35 %) after a mean follow-up of 20 months (range 3 - 84 months). In the remaining seven patients (35 %), initial lesions did not progress to ulcerative colitis and did not go into remission during a mean follow-up of 16.9 months (range 2 - 42 months). These results suggest that, at least in some cases, AOI precedes development of ulcerative colitis.

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Appendicitis / complications*
  • Appendicitis / drug therapy
  • Appendicitis / pathology*
  • Colitis, Ulcerative / complications*
  • Colitis, Ulcerative / pathology
  • Colonoscopy
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Mesalamine / therapeutic use
  • Middle Aged
  • Remission, Spontaneous
  • Time Factors
  • Young Adult

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Mesalamine