Effect of adaptive servo-ventilation on 1-year prognosis in heart failure patients

Circ J. 2012;76(3):661-7. doi: 10.1253/circj.cj-11-0299. Epub 2011 Dec 23.


Background: Adaptive servo-ventilation (ASV) has been used as therapy for heart failure (HF). The objective of the present study was to estimate the effect of ASV on 1-year prognosis in HF patients.

Methods and results: After optimizing medical therapy, a 1-year follow-up study was conducted of 85 HF patients (mean age, 72 ± 10 years; 46 men), categorized as New York Heart Association class II-IV. The patients were classified into 2 groups based on adherence to ASV therapy. Use of ASV for ≥ 4h/night was designated as good adherence, and use of ASV for <4h/night was designated as poor adherence. The incidence of fatal cardiovascular events including death from progression of HF, cardioembolic stroke, and fatal cardiac arrhythmias was tracked. Fifty-seven patients were classified into the good adherence group. After 1-year follow-up, the survival rate calculated using Kaplan-Meier analysis was significantly higher in the good adherence group than in the poor adherence group (P=0.0046, log-rank test). In a Cox proportional hazards model, the odds ratio (95% confidence interval) of fatal cardiovascular events was 0.53 (0.27-0.99) for the good ASV adherence group (P=0.046).

Conclusions: ASV prevents fatal cardiovascular events and improves survival in HF patients.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Female
  • Follow-Up Studies
  • Heart Failure / mortality
  • Heart Failure / therapy*
  • Humans
  • Interactive Ventilatory Support / instrumentation
  • Interactive Ventilatory Support / methods*
  • Interactive Ventilatory Support / standards
  • Male
  • Middle Aged
  • Patient Compliance
  • Prognosis
  • Respiration, Artificial / methods
  • Survival Rate
  • Treatment Outcome