Dnmt3a silences hematopoietic stem cell self-renewal

Jennifer J Trowbridge; Stuart H Orkin

doi:10.1038/ng.1043

Dnmt3a silences hematopoietic stem cell self-renewal

Nat Genet. 2011 Dec 27;44(1):13-4. doi: 10.1038/ng.1043.

Authors

Jennifer J Trowbridge¹, Stuart H Orkin

Affiliation

¹ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts, USA. trowbridge@bloodgroup.tch.harvard.edu

PMID: 22200773
DOI: 10.1038/ng.1043

Abstract

DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

MeSH terms

Cell Differentiation / genetics
Cell Division / genetics*
DNA (Cytosine-5-)-Methyltransferases / genetics*
DNA Methylation
DNA Methyltransferase 3A
Hematopoietic Stem Cells / physiology*
RNA Interference*

Substances

DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A