Abstract
DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.
MeSH terms
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Cell Differentiation / genetics
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Cell Division / genetics*
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DNA (Cytosine-5-)-Methyltransferases / genetics*
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DNA Methylation
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DNA Methyltransferase 3A
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Hematopoietic Stem Cells / physiology*
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RNA Interference*
Substances
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DNA (Cytosine-5-)-Methyltransferases
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DNA Methyltransferase 3A