Dnmt3a silences hematopoietic stem cell self-renewal

Nat Genet. 2011 Dec 27;44(1):13-4. doi: 10.1038/ng.1043.


DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

MeSH terms

  • Cell Differentiation / genetics
  • Cell Division / genetics*
  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • DNA Methylation
  • DNA Methyltransferase 3A
  • Hematopoietic Stem Cells / physiology*
  • RNA Interference*


  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A