[A long-term survival case of recurrent pancreatic vipoma with liver metastases treated by a combination of surgical resection and loco-regional therapies]

Gan To Kagaku Ryoho. 2011 Nov;38(12):2158-60.
[Article in Japanese]


We report a case of recurrent pancreatic VIPoma with liver and peritoneal metastases who has been surviving over 7 years by a successful treatment with a combination of surgical resection and loco-regional therapies. A 59-year-old female underwent distal pancreatectomy for pancreatic endocrine tumor. Five years after pancreatectomy, she had a recurrence of liver and peritoneal metastases with the symptoms by hypersecretion of VIP, and she underwent hepatectomy and peritoneal tumor resection. Seven months later, multiple liver metastases appeared and were treated with transcatheter arterial chemoembolization (TACE). Additionally radiofrequency ablation( RFA) for remnant viable lesion was performed. Seven years and eight months after primary panceatectomy and two years and six months after resection of the liver and peritoneal recurrences, she is now disease-free with good quality of life. The progression of well-differentiated pancreatic neuroendocrine carcinoma is usually slow. It is potentially useful in controlling of liver metastases to combine the loco-regional therapy like TACE and RFA with surgical resection.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Female
  • Humans
  • Liver Neoplasms / secondary
  • Liver Neoplasms / therapy*
  • Middle Aged
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / therapy*
  • Quality of Life
  • Recurrence
  • Time Factors
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Vipoma / pathology
  • Vipoma / therapy*