Abstract
We describe the activities of RX-P763, RX-P766, RX-P770, RX-P792, RX-P793, and RX-P808 against strains of resistant Pseudomonas aeruginosa. These compounds target the large subunit of the bacterial ribosome and have broad-spectrum activities against multidrug-resistant pathogens. All compounds demonstrated in vitro activity against P. aeruginosa, with MIC(90) values of 4 to 8 μg/ml (range, 0.5 to 64). These novel compounds had narrow MIC distributions and maintained activity despite resistance phenotypes to other commonly utilized agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / pharmacology*
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Ciprofloxacin / pharmacology
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Cytosine / analogs & derivatives*
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Cytosine / chemical synthesis
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Cytosine / pharmacology*
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Drug Resistance, Multiple, Bacterial*
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Humans
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Microbial Sensitivity Tests
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / growth & development
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Pseudomonas aeruginosa / isolation & purification
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Pyrroles / chemical synthesis
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Pyrroles / pharmacology*
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Ribosome Subunits, Large, Bacterial
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Tobramycin / pharmacology
Substances
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Anti-Bacterial Agents
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Pyrroles
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Ciprofloxacin
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Cytosine
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Tobramycin