The use of pluripotent stem cell for personalized cell therapies against neurological disorders

J Biomed Biotechnol. 2011;2011:520816. doi: 10.1155/2011/520816. Epub 2011 Dec 13.


Although there are a number of weaknesses for clinical use, pluripotent stem cells are valuable sources for patient-specific cell therapies against various diseases. Backed-up by a huge number of basic researches, neuronal differentiation mechanism is well established and pluripotent stem cell therapies against neurological disorders are getting closer to clinical application. However, there are increasing needs for standardization of the sourcing pluripotent stem cells by establishing stem cell registries and banking. Global harmonization will accelerate practical use of personalized therapies using pluripotent stem cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation / physiology
  • Cell- and Tissue-Based Therapy / methods*
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / physiology*
  • Embryonic Stem Cells / transplantation
  • Humans
  • Induced Pluripotent Stem Cells / physiology*
  • Induced Pluripotent Stem Cells / transplantation
  • Nervous System Diseases / pathology
  • Nervous System Diseases / therapy*
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / transplantation*
  • Stem Cell Transplantation