Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery

Curr Pharm Des. 2011 Dec;17(38):4308-17. doi: 10.2174/138161211798999393.


This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Drug Discovery / methods*
  • Helianthus* / metabolism
  • Humans
  • Molecular Sequence Data
  • Peptides, Cyclic* / biosynthesis
  • Peptides, Cyclic* / chemical synthesis
  • Peptides, Cyclic* / chemistry
  • Peptides, Cyclic* / pharmacology
  • Solid-Phase Synthesis Techniques
  • Structure-Activity Relationship


  • Peptides, Cyclic
  • SFTI-1 peptide, sunflower