Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 217 (3), 687-718

Brainpeps: The Blood-Brain Barrier Peptide Database

Affiliations
Review

Brainpeps: The Blood-Brain Barrier Peptide Database

Sylvia Van Dorpe et al. Brain Struct Funct.

Abstract

Peptides are able to cross the blood-brain barrier (BBB) through various mechanisms, opening new diagnostic and therapeutic avenues. However, their BBB transport data are scattered in the literature over different disciplines, using different methodologies reporting different influx or efflux aspects. Therefore, a comprehensive BBB peptide database (Brainpeps) was constructed to collect the BBB data available in the literature. Brainpeps currently contains BBB transport information with positive as well as negative results. The database is a useful tool to prioritize peptide choices for evaluating different BBB responses or studying quantitative structure-property (BBB behaviour) relationships of peptides. Because a multitude of methods have been used to assess the BBB behaviour of compounds, we classified these methods and their responses. Moreover, the relationships between the different BBB transport methods have been clarified and visualized.

Similar articles

See all similar articles

Cited by 20 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback