Latent autoimmune diabetes of adults is phenotypically similar to type 1 diabetes in a minority population

J Clin Endocrinol Metab. 2012 Mar;97(3):E409-13. doi: 10.1210/jc.2011-2544. Epub 2011 Dec 28.


Context: Latent autoimmune diabetes of adults (LADA) is a form of autoimmune diabetes that has been classified as part of type 1 diabetes or as a distinct clinical entity. Its precise place as a disease category is therefore controversial.

Objective: The objective of this study was to further examine this issue by comparing the phenotypes of LADA and type 1 diabetes in a predominately minority population.

Patients and methods: We studied 126 subjects who were anti-glutamic acid decarboxylase antibody-positive in two separate studies--63 subjects in an outpatient study (study 1), and 63 inpatients after resolution of ketoacidosis (study 2). Clinical and biochemical phenotyping was performed in all patients in each group.

Results: Few significant differences were found in the clinical or biochemical phenotypes in patients classified as LADA when compared with type 1 diabetes. Adiposity, body mass index, waist/hip ratio, fasting plasma C-peptide, serum high-density lipoprotein cholesterol, and triglycerides were all similar. The only distinguishing feature was a history of hypertension (study 1) or systolic blood pressure (study 2). Also, a history of ketoacidosis did not influence the phenotype of LADA in the outpatients in any discernable way.

Conclusions: We conclude that LADA and type 1 diabetes are phenotypically indistinguishable in this predominantly minority population with a mean duration of glutamic acid decarboxylase antibody-positive diabetes of about 8 yr.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Age of Onset
  • Autoantibodies / immunology*
  • Autoimmune Diseases / diagnosis*
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / physiopathology
  • Blood Glucose
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / physiopathology
  • Female
  • Glutamate Decarboxylase / immunology*
  • Humans
  • Ketosis / diagnosis
  • Ketosis / immunology
  • Ketosis / physiopathology
  • Male
  • Middle Aged
  • Minority Health
  • Phenotype


  • Autoantibodies
  • Blood Glucose
  • Glutamate Decarboxylase