Abstract
Among different coronavirus genera, the receptor-binding S1 subunits of their spike proteins differ in primary, secondary, and tertiary structures. This study identified shared structural topologies (connectivity of secondary structural elements) in S1 domains of different coronavirus genera. The results suggest that coronavirus S1 subunits share a common evolutionary origin but have attained diverse sequences and structures following extensive divergent evolution. The results also increase understanding of the structures and functions of coronavirus S1 domains whose tertiary structures are currently unknown.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Binding Sites
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Cell Line
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Coronavirus / chemistry
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Coronavirus / classification
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Coronavirus / genetics*
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Coronavirus / metabolism
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Coronavirus Infections / genetics
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Coronavirus Infections / metabolism*
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Coronavirus Infections / virology
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Evolution, Molecular*
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Humans
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / genetics*
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Membrane Glycoproteins / metabolism
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Models, Molecular
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Molecular Sequence Data
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Protein Binding
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Protein Structure, Tertiary
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Receptors, Virus / genetics
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Receptors, Virus / metabolism*
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Spike Glycoprotein, Coronavirus
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Viral Envelope Proteins / chemistry
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Viral Envelope Proteins / genetics*
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Viral Envelope Proteins / metabolism
Substances
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Membrane Glycoproteins
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Receptors, Virus
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Spike Glycoprotein, Coronavirus
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Viral Envelope Proteins