Group B Streptococcus surface proteins as major determinants for meningeal tropism

Curr Opin Microbiol. 2012 Feb;15(1):44-9. doi: 10.1016/j.mib.2011.12.002. Epub 2011 Dec 27.


Streptococcus agalactiae (group B Streptococcus, GBS), a normal constituent of the intestinal microbiota is the major cause of human neonatal infections and a worldwide spread 'hypervirulent' clone, GBS ST-17, is strongly associated with neonatal meningitis. Adhesion to epithelial and endothelial cells constitutes a key step of the infectious process. Therefore GBS surface-anchored proteins are obvious potential adhesion mediators of barrier crossing and determinant of hypervirulence. This review addresses the most recent molecular insights gained from studies on GBS surface proteins proven to be involved in the crossing of the brain-blood barrier and emphasizes on the specificity of a hypervirulent clone that displays meningeal tropism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood-Brain Barrier / microbiology
  • Humans
  • Membrane Proteins / metabolism*
  • Meninges / microbiology*
  • Streptococcus agalactiae / growth & development
  • Streptococcus agalactiae / pathogenicity*
  • Tropism*
  • Virulence Factors / metabolism*


  • Membrane Proteins
  • Virulence Factors