A new oral otoprotective agent. Part 1: Electrophysiology data from protection against noise-induced hearing loss

Med Sci Monit. 2012 Jan;18(1):BR1-8. doi: 10.12659/msm.882180.


Background: Data from animal studies show that antioxidants can compensate against noise-induced stress and sensory hair cell death. The aim of this study was to evaluate the otoprotection efficacy of various versions of orally administered Acuval 400 against noise damage in a rat animal model.

Material/methods: Fifty-five Sprague Dawley rats were divided into 4 groups: A) noise-exposed animals; B) animals exposed to noise and treated with the Acuval; C) animals exposed to noise and treated with a combination of Coenzyme Q10 and Acuval; D) animals treated only with Acuval and Coenzyme Q10 and with no exposure to noise. All solutions were administered orally 5 times: 24 and 2 hrs prior to noise exposure, and then daily for 3 days. The auditory function was assessed by measuring auditory brainstem responses (ABR) in the range from 2 to 32 kHz at times =1, 7, 14 and 21 days after noise exposure.

Results: At low frequencies (click and 4 kHz) animals from both A and B groups showed significant threshold shifts in the majority of the tested frequencies and tested times. For the same frequencies, animals from group C presented threshold levels similar to those from group D. At frequencies ≥ 8 kHz the protective performance of the 2 Acuval groups is more clearly distinguished from the noise group A. At 32 kHz the 2 Acuval groups perform equally well in terms of otoprotection. Animals in Group D did not show any significant differences in the hearing threshold during the experiment.

Conclusions: The data of this study suggest that a solution containing Coenzyme Q10 and Acuval 400, administered orally, protects from noise-induced hearing loss.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Evoked Potentials, Auditory, Brain Stem / physiology
  • Hair Cells, Auditory / drug effects*
  • Hearing Loss, Noise-Induced / prevention & control*
  • Likelihood Functions
  • Models, Statistical
  • Protective Agents / administration & dosage
  • Protective Agents / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives
  • Ubiquinone / pharmacology
  • Vitamins / administration & dosage
  • Vitamins / pharmacology*


  • Protective Agents
  • Vitamins
  • Ubiquinone
  • coenzyme Q10