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Comparative Study
. Jul-Aug 2012;33(4):518-23.
doi: 10.1097/BCR.0b013e31823746ed.

Catechol-O-methyltransferase Genotype Predicts Pain Severity in Hospitalized Burn Patients

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Free PMC article
Comparative Study

Catechol-O-methyltransferase Genotype Predicts Pain Severity in Hospitalized Burn Patients

Danielle C Orrey et al. J Burn Care Res. .
Free PMC article

Abstract

Increasing evidence suggests that stress system activation after burn injury may contribute to burn-related pain. If this is the case, then genetic variations influencing the function of important stress system components, such as the enzyme catechol-O-methyltransferase (COMT), may predict pain severity after thermal burn injury. The authors evaluated the association between COMT genotype and pain intensity in 57 individuals hospitalized after thermal burn injury. Consenting participants at four burn centers were genotyped and completed daily 0 to 10 numeric rating scale pain assessments on 2 consecutive days including evaluation of waking, least, and worst pain. The association between COMT genotype and individual pain outcomes was calculated using a linear mixed model adjusting for sociodemographic and burn injury characteristics. Overall pain (combination of least, worst, and waking pain scores) was significantly higher in patients with a COMT pain vulnerable genotype (6.3 [0.4] vs 5.4 [0.4], P = .037). Individuals with a COMT pain vulnerable genotype also had significantly higher "least pain" scores (3.8 [0.5] vs 2.6 [0.4], P = .017) and significantly higher pain on awakening (6.8 [0.5] vs 5.3 [0.4], P = .004). Differences in worst pain according to genotype group were not significant. COMT pain vulnerable genotype was a stronger predictor of overall pain severity than burn size, burn depth, or time from admission to pain interview assessment. These findings suggest that genetic factors influencing stress system function may have an important influence on pain severity after burn injury. Further studies of genetic predictors of pain after burn injury are needed.

Conflict of interest statement

Conflicts: Danielle C. Orrey reported no conflicts of interest

Conflicts: Andrey V. Bortsov reported no conflicts of interest

Conflicts: Janelle M. Hoskins reported no conflicts of interest

Conflicts: Jeffrey W. Shupp reported no conflicts of interest

Conflicts: Samuel W. Jones reported no conflicts of interest

Conflicts: Bryan J. Cicuto received honoraria from Baxter ARTISS [Fibrin Sealant (Human)] and from the EXIGO Management Consultants Professional Opinion Survey: Wound Care/Burn Care, and received research funding from Ethicon Education Grants

Conflicts: James Hwang reported no conflicts of interest

Conflicts: Marion H. Jordan reported no conflicts of interest

Conflicts: James H. Holmes reported no conflicts of interest

Conflicts: Linwood R. Haith reported no conflicts of interest

Conflicts: Brandon M. Roane reported no conflicts of interest

Conflicts: Luda Diatchenko consulted for Algynomics, has equity interest in Algynomics, and reported a conflict of interest with Algynomics

Conflicts: Bruce A. Cairns reported no conflicts of interest

Conflicts: Samuel A. McLean reported no conflicts of interest

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