Influence of patient-related variables on clozapine plasma levels

Am J Psychiatry. 1990 Nov;147(11):1471-5. doi: 10.1176/ajp.147.11.1471.


The authors investigated the clozapine plasma levels of 148 psychiatric inpatients. Multiple regression analysis revealed a linear relationship between dose of clozapine and plasma concentrations. The analysis showed a significant influence of dose, sex, smoking, weight, and age on the plasma concentrations of clozapine under clinical conditions. These results remained significant when clozapine doses below 150 mg/day and above 500 mg/day were excluded from the analysis.

MeSH terms

  • Adult
  • Age Factors
  • Analysis of Variance
  • Body Weight
  • Clozapine / administration & dosage
  • Clozapine / blood*
  • Dose-Response Relationship, Drug
  • Female
  • Hospitalization
  • Humans
  • Male
  • Mental Disorders / blood*
  • Mental Disorders / drug therapy
  • Sex Factors
  • Smoking / psychology


  • Clozapine