Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations

J Cell Biochem. 2012 May;113(5):1460-9. doi: 10.1002/jcb.24046.


There is currently great interest in the use of mesenchymal stem/stromal cells (MSCs) for the therapy of many diseases of animals and humans. However, we are still left with the serious challenges in explaining the beneficial effects of the cells. Hence, it is essential to work backward from dramatic results obtained in vivo to the cellular and molecular explanations in order to discover the secrets of MSCs. This review will focus on recent data that have changed the paradigms for understanding the therapeutic potentials of MSCs.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adult Stem Cells / immunology
  • Adult Stem Cells / physiology
  • Adult Stem Cells / transplantation*
  • Animals
  • Apoptosis
  • Humans
  • Inflammation / therapy
  • Mesenchymal Stem Cell Transplantation*
  • Mesenchymal Stem Cells / immunology
  • Mesenchymal Stem Cells / physiology
  • Translational Research, Biomedical
  • Wound Healing