Active conformation of seven-membered-ring benzolactams as new ACAT inhibitors: latent chirality at N5 in the 1,5-benzodiazepin-2-one nucleus

Chemistry. 2012 Feb 6;18(6):1572-6. doi: 10.1002/chem.201103264. Epub 2011 Dec 28.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzodiazepines / chemical synthesis
  • Benzodiazepines / chemistry*
  • Benzodiazepines / pharmacology*
  • Circular Dichroism
  • Crystallography, X-Ray
  • Microsomes, Liver / drug effects
  • Molecular Conformation
  • Molecular Structure
  • Rabbits
  • Stereoisomerism
  • Sterol O-Acyltransferase / antagonists & inhibitors*

Substances

  • 1,5-benzodiazepin-2-one
  • Benzodiazepines
  • Sterol O-Acyltransferase