Drug interaction between lenalidomide and itraconazole

Am J Hematol. 2012 Mar;87(3):338-9. doi: 10.1002/ajh.22260. Epub 2011 Dec 27.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors
  • Antibiotic Prophylaxis
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Area Under Curve
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 CYP3A Inhibitors
  • Dexamethasone / administration & dosage
  • Female
  • Humans
  • Intestinal Absorption / drug effects
  • Itraconazole / pharmacokinetics*
  • Itraconazole / therapeutic use
  • Lenalidomide
  • Melphalan / administration & dosage
  • Middle Aged
  • Multiple Myeloma / drug therapy*
  • Neutropenia / chemically induced*
  • Prednisone / administration & dosage
  • Thalidomide / administration & dosage
  • Thalidomide / adverse effects
  • Thalidomide / analogs & derivatives*
  • Thalidomide / pharmacokinetics

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Cytochrome P-450 CYP3A Inhibitors
  • Itraconazole
  • Thalidomide
  • Dexamethasone
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Lenalidomide
  • Melphalan
  • Prednisone