Effect of vitamin C on histamine bronchial responsiveness of patients with allergic rhinitis

Ann Allergy. 1990 Oct;65(4):311-4.


The effect of acute oral administration of 2 g vitamin C on bronchial responsiveness to inhaled histamine in 16 patients with allergic rhinitis was compared with placebo on two consecutive days in a double-blind, crossover design. The PC15FEV1 was significantly increased one hour after treatment with vitamin C but not after placebo.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Administration, Inhalation
  • Adult
  • Ascorbic Acid / blood
  • Ascorbic Acid / pharmacology*
  • Bronchi / drug effects*
  • Double-Blind Method
  • Female
  • Forced Expiratory Volume
  • Histamine / administration & dosage*
  • Humans
  • Male
  • Maximal Expiratory Flow Rate
  • Rhinitis, Allergic, Seasonal / drug therapy
  • Rhinitis, Allergic, Seasonal / physiopathology*


  • Histamine
  • Ascorbic Acid