The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis

Genes Dev. 2012 Jan 1;26(1):6-10. doi: 10.1101/gad.184416.111.


Differentiation of multipotent stem cells occurs through the highly coordinated control of gene expression. Repressor element 1 (RE1) silencing transcription factor (REST), a master transcriptional regulator in neuronal stem cells, restricts neuronal gene expression. REST activity is context-dependent and is modified by its cofactors, such as Ctdsp2. In this issue of Genes & Development, Dill and colleagues (pp. 25-30) report on the microRNA-mediated regulation of neural differentiation. Interestingly, this microRNA is post-transcriptionally regulated and modulates expression of its host gene, ctdsp2.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cell Differentiation*
  • Gene Expression Regulation, Developmental*
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism*
  • Neurons / cytology*
  • Neurons / metabolism*
  • Phosphoprotein Phosphatases / genetics*
  • Zebrafish Proteins / genetics*


  • MicroRNAs
  • Mirn26 microRNA, zebrafish
  • Zebrafish Proteins
  • CTDSP2 protein, zebrafish
  • Phosphoprotein Phosphatases