Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011;2011:948328.
doi: 10.1155/2011/948328. Epub 2011 Dec 14.

Neuroendocrine Carcinoma of the Stomach: A Case Study

Affiliations
Free PMC article
Case Reports

Neuroendocrine Carcinoma of the Stomach: A Case Study

Keisuke Kubota et al. Case Rep Med. .
Free PMC article

Abstract

Gastric neuroendocrine carcinomas are rare and have a poor prognosis, and the diagnostic criteria for this disease have recently changed. We herein report a case of sporadic gastric neuroendocrine carcinoma. A 75-year-old man was referred to our hospital with epigastric pain. Endoscopic examination revealed a localized ulcerative lesion (diameter, 4 cm) at the upper stomach. The diagnosis on biopsy was neuroendocrine carcinoma. Total gastrectomy with D2 lymphadenectomy, splenectomy, and cholecystectomy was performed. Pathologically, the tumor infiltrated the subserosal layer, and 6/49 lymph nodes were involved. The tumor was uniform in shape and arranged in a rosette-like structure to form solid nests, with medium-sized, round-to-cuboid-shaped tumor cells and intense mitosis 46/10 HPF. It was positive for synaptophysin and chromogranin A, and the Ki-67 labeling index was 70-80%. The diagnosis of neuroendocrine carcinoma was made according to the WHO 2010 criteria. The patient was followed up for three years without recurrence.

Figures

Figure 1
Figure 1
Upper endoscopic examination revealed a localized ulcerative lesion (diameter, 4 cm) located on the lesser curvature of the upper stomach.
Figure 2
Figure 2
Histological findings of the tumor (x 400). The tumor was uniform in shape and arranged in small microtubular structures (rosette-like arrangement) to form solid nests, with medium-sized, round-to-cuboid-shaped tumor cells. The tumor cells exhibited intense mitosis greater than 2/HPF (hematoxylin and eosin, (a)). Immunohistochemical staining showed that it was positive for synaptophysin (b) and chromogranin A (c). The Ki-67 labeling index was 70–80% (d).

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Rindi G, Luinetti O, Cornaggia M, Capella C, Solcia E. Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study. Gastroenterology. 1993;104(4):994–1006. - PubMed
    1. Rindi G, Bordi C, Rappel S, la Rosa S, Stolte M, Solcia E. Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior. World Journal of Surgery. 1996;20(2):168–172. - PubMed
    1. Rindi G. Clinicopathologic aspects of gastric neuroendocrine tumors. American Journal of Surgical Pathology. 1995;19(supplement 1):S20–S29. - PubMed
    1. Waisberg J, de Matos LL, Mader AMDAA, et al. Neuroendocrine gastric carcinoma expressing somatostatin: a highly malignant, rare tumor. World Journal of Gastroenterology. 2006;12(24):3944–3947. - PMC - PubMed
    1. Matsui K, Jin XM, Kitagawa M, Miwa A. Clinicopathologic features of neuroendocrine carcinomas of the stomach: appraisal of small cell and large cell variants. Archives of Pathology and Laboratory Medicine. 1998;122(11):1010–1017. - PubMed

Publication types

Feedback