Mesoporous silica nanoparticles in biomedical applications

Chem Soc Rev. 2012 Apr 7;41(7):2590-605. doi: 10.1039/c1cs15246g. Epub 2012 Jan 3.


This tutorial review provides an outlook on nanomaterials that are currently being used for theranostic purposes, with a special focus on mesoporous silica nanoparticle (MSNP) based materials. MSNPs with large surface area and pore volume can serve as efficient carriers for various therapeutic agents. The functionalization of MSNPs with molecular, supramolecular or polymer moieties, provides the material with great versatility while performing drug delivery tasks, which makes the delivery process highly controllable. This emerging area at the interface of chemistry and the life sciences offers a broad palette of opportunities for researchers with interests ranging from sol-gel science, the fabrication of nanomaterials, supramolecular chemistry, controllable drug delivery and targeted theranostics in biology and medicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomedical Technology*
  • Drug Delivery Systems*
  • Ferric Compounds / chemistry
  • Gold / chemistry
  • Humans
  • Metal Nanoparticles / chemistry*
  • Micelles
  • Porosity
  • Silicon Dioxide / chemistry*


  • Ferric Compounds
  • Micelles
  • ferric oxide
  • Gold
  • Silicon Dioxide