Cholesterol and vitamins: revisited study

J Biol Regul Homeost Agents. 2011 Oct-Dec;25(4):505-15.


The link between low density lipoprotein and coronary heart disease has been widely studied. Oxidized LDL damages the artery wall, and a diet rich in vitamins and low in saturated fat and cholesterol may reduce this risk. Not only hypercholesterolemia but also low levels of high density lipoprotein cholesterol are critical risk factors for atherosclerosis and related diseases. It has been reported that high doses of B complex vitamin may be useful in lowering blood cholesterol and triglyceride levels in the body, however the use of this compound has been limited by an annoying flush and concern for toxicity. Niacin is a B-complex vitamin with anti-atherosclerotic properties and is an effective medication for raising high density lipoprotein. The combination of niacin with other lipid-lowering drugs, such as statins, reduces the dynamic of atherosclerosis disease. In addition, vitamin E is one of the most important lipid soluble anti-oxidants in humans, and reduces atherosclerosis plaque, coronary artery diseases and myocardial infarction. Vitamin E protects the integrity of membranes by inhibiting lipid peroxidation. In this study we revisited the interrelationship between cholesterol, low density lipoproteins and vitamins.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Atherosclerosis / prevention & control*
  • Cardiovascular Diseases / prevention & control*
  • Cholesterol / blood*
  • Diabetes Mellitus, Type 2 / complications
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Niacin / administration & dosage
  • Vitamin E / pharmacology
  • Vitamins / administration & dosage*


  • Antioxidants
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Vitamins
  • Vitamin E
  • Niacin
  • Cholesterol