Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study

Braz J Infect Dis. Nov-Dec 2011;15(6):533-9. doi: 10.1590/s1413-86702011000600006.

Abstract

Objective: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality.

Methods: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis.

Results: Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively).

Conclusion: The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Abortion, Spontaneous / microbiology
  • Chlamydia Infections / diagnosis
  • Chlamydia Infections / mortality*
  • Endometritis / microbiology
  • Female
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Obstetric Labor, Premature / microbiology
  • Perinatal Mortality*
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis
  • Pregnancy Complications, Infectious / microbiology
  • Pregnancy Complications, Infectious / mortality*
  • Risk Factors
  • Uterine Cervicitis / diagnosis
  • Uterine Cervicitis / microbiology
  • Uterine Cervicitis / mortality*