The integration and annotation of the human interactome in the UniHI Database

Methods Mol Biol. 2012;812:175-88. doi: 10.1007/978-1-61779-455-1_10.


In recent years, remarkable progress has been made toward the systematic charting of human protein interactions. The utilization of the generated interaction data remained however challenging for biomedical researchers due to lack of integration of currently available resources. To facilitate the direct access and analysis of the human interactome, we have developed the Unified Human Interactome (UniHI) database. It provides researchers with a user-friendly Web-interface and integrates interaction data from 12 major resources in its latest version, establishing one of the largest catalogs for human PPIs worldwide. At present, UniHI houses over 250,000 distinct interactions between 22,300 unique proteins and is publically available at

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Graphics
  • Databases, Protein*
  • Humans
  • Internet
  • Molecular Sequence Annotation / methods*
  • Organ Specificity
  • Protein Interaction Mapping / methods*
  • Proteins / metabolism*
  • User-Computer Interface


  • Proteins