Identification of two voltage-dependent anion channel-like protein sequences conserved in Kinetoplastida

Nadine Flinner; Enrico Schleiff; Oliver Mirus

doi:10.1098/rsbl.2011.1121

Identification of two voltage-dependent anion channel-like protein sequences conserved in Kinetoplastida

Biol Lett. 2012 Jun 23;8(3):446-9. doi: 10.1098/rsbl.2011.1121. Epub 2012 Jan 4.

Authors

Nadine Flinner¹, Enrico Schleiff, Oliver Mirus

Affiliation

¹ Department of Biosciences, Molecular Cell Biology of Plants, Goethe University Frankfurt, Frankfurt, Hesse, Germany.

Abstract

The eukaryotic porin superfamily consists of two families, voltage-dependent anion channel (VDAC) and Tom40, which are both located in the mitochondrial outer membrane. In Trypanosoma brucei, only a single member of the VDAC family has been described. We report the detection of two additional eukaryotic porin-like sequences in T. brucei. By bioinformatic means, we classify both as putative VDAC isoforms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Molecular Sequence Data
Protozoan Proteins / genetics*
Protozoan Proteins / metabolism
Sequence Deletion
Trypanosoma brucei brucei / chemistry
Trypanosoma brucei brucei / genetics*
Voltage-Dependent Anion Channels / genetics*
Voltage-Dependent Anion Channels / metabolism

Substances

Protozoan Proteins
Voltage-Dependent Anion Channels