Androgen receptors, serum androgen levels and survival of breast cancer patients

Arch Gynecol Obstet. 1990;247(4):203-9. doi: 10.1007/BF02389545.

Abstract

Steroid receptor levels and serum androgen levels were determined in 61 breast cancer patients and 34 patients with non-malignant breast lesions. Testosterone and dehydroepiandrosterone-sulfate did not and androstenedione did show a difference between the two groups. Androgen levels had no influence on survival rates. Androgen receptor (AR) levels correlated with progesterone receptor levels, but not with estrogen receptor levels or with tumor stage. Patients with positive AR findings had a better survival rate; this was independent of tumor stage. AR findings may therefore be a prognostic index in breast cancer patients.

MeSH terms

  • Adult
  • Aged
  • Androgens / blood*
  • Breast / chemistry
  • Breast Neoplasms / blood*
  • Breast Neoplasms / mortality
  • Breast Neoplasms / pathology
  • Female
  • Fibrocystic Breast Disease / blood*
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Neoplasm Staging
  • Neoplasms, Hormone-Dependent / blood*
  • Receptors, Androgen / metabolism*
  • Receptors, Estrogen / metabolism
  • Receptors, Progesterone / metabolism
  • Survival Rate

Substances

  • Androgens
  • Receptors, Androgen
  • Receptors, Estrogen
  • Receptors, Progesterone