Immediate effects of monochromatic infrared energy on microcirculation in healthy subjects

Photomed Laser Surg. 2012 Apr;30(4):193-9. doi: 10.1089/pho.2011.3012. Epub 2012 Jan 5.


Objective: The purpose of this study was to evaluate the influence of monochromatic infrared energy (MIRE) on the microcirculation of the skin surface of the feet in healthy subjects.

Background data: Near-infrared energy was shown to increase microcirculation in an animal study. In humans, only one case study demonstrated that MIRE increases microcirculation in the skin of the lower limbs.

Methods: Thirty healthy volunteers were recruited and randomly allocated into three groups to receive either: (1) active MIRE; (2) sham MIRE (placebo group); or (3) warm packs (control group) on the feet. The MIRE device comprised an array of 60 x 890 nm LEDs attached to flexible pads (3×7.5 cm). Each diode spot size was 0.2 cm(2), and each LED power was 12 mW with a power density of 60 mW/cm(2). The arrays were placed in direct contact with the skin for 30 min delivering a total fluence of 108 J/cm(2) over an area of 22.5 cm(2). Capillary blood cell velocity (CBV) and superficial skin blood flow (flux) were recorded before and after intervention.

Results: Significant differences among the three groups were recorded in both CBV and flux (both p<0.05). Post-hoc comparisons indicated that a significantly greater increase in both CBV and flux occurred in the active MIRE group than in the placebo group and control group (all p<0.05).

Conclusions: A 30-min MIRE produced a significantly greater increase in the CBV and flux of the feet in the active MIRE group than in the placebo and control groups.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • China
  • Female
  • Foot / blood supply
  • Foot / radiation effects
  • Humans
  • Infrared Rays*
  • Male
  • Microcirculation / physiology
  • Microcirculation / radiation effects*
  • Middle Aged
  • Radiation Dosage
  • Reference Values
  • Single-Blind Method
  • Skin / blood supply*
  • Skin / radiation effects
  • Time Factors
  • Young Adult