Female long-term survivors after allogeneic hematopoietic stem cell transplantation: evaluation and management

Semin Hematol. 2012 Jan;49(1):83-93. doi: 10.1053/j.seminhematol.2011.10.002.


Female long-term survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) incur a significant burden of late effects. Genital graft-versus-host disease (GVHD), human papillomavirus (HPV) reactivation, ovarian failure and infertility, sexual dysfunction, and osteoporosis are concerns that can significantly impact quality of life. This review examines the risk, pathogenesis, clinical presentation, and implications of these common complications. Recommendations are provided for evaluation and management of these late effects and other obstetric and gynecologic issues that may arise in this patient population.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Female
  • Graft vs Host Disease / complications
  • Graft vs Host Disease / etiology*
  • Graft vs Host Disease / therapy*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Infertility, Female / complications*
  • Infertility, Female / therapy
  • Osteoporosis / complications*
  • Osteoporosis / therapy
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / therapy
  • Papillomavirus Infections / virology
  • Survivors*
  • Time Factors
  • Transplantation, Homologous